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Coumarins Suitable for Various Uses including Cell Biological Analyses
Coumarin with enhanced photocleavage efficiency and improved hydrolysis resistance useful as various photoconductive molecular tools
Background
Coumarin fluorescent dyes can be photolyzed by various visible light wavelengths and have been utilized as molecular tools to understand cellular biological functions and as stimuli-responsive materials. However, enhancing the efficiency of photocleavage makes them more susceptible to hydrolysis, making it difficult to develop efficient photoconductive molecular tools.
Description and Advantages
Kyoto University researchers successfully enhanced the photocleavage efficiency of coumarin by introducing a silyl group, which chemically stabilizes the photoexcited species. Additionally, the bulkiness of this substituent itself contributed to improving hydrolysis resistance.
- Useful as a new caged compounds
- Further development opportunities of biologically active substances with light-controllable properties by bioconjugation
- Various applications by using the new coumarin as a compound precursor
- Applicable to coumarins with various spectral characteristics
| Development Status |
TRL: Level 1 Prototype development of a tool that releases proteins via light control Further optimization opportunities for desired uses and properties |
|---|---|
| Offer | Patent License Option for License MTA for sample testing Collaborative Research |
| Related Links | View PDF |
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- Coumarins Suitable for Various Uses including Cell Biological Analyses
3rd Floor, International Science
Innovation Building, Kyoto University
Yoshidahonmachi, Sakyo-ku, Kyoto
600-8501 JAPAN